Engineering active siRNA therapeutics
نویسندگان
چکیده
منابع مشابه
What is the Future of SiRNA Therapeutics?
RNA interference (RNAi) – gene silencing by double-stranded RNA, is a Nobel Prize winning discovery by Fire and Mellow [1]. Since RNAi was found to occur in mammalian cells, it has been intensively investigated as a new therapeutic strategy. RNAi can be triggered by the introduction of synthetic sequence-specific small interfering RNA (siRNA), which is able to target and cleave complementary me...
متن کاملAntibody Engineering and Therapeutics
note: The views expressed herein are those of the authors and do not necessarily reflect the views of their respective employers. Speakers who wrote a summary of their own presentation are listed in the header for the relevant session. The majority of the other summaries in this report were based on PDFs of the presentations provided by speakers or on post-meeting input from the speakers. The a...
متن کاملEngineering Ribonuclease - Based Cancer Therapeutics
............................................................................................................................ i Acknowledgements ............................................................................................................ iv Table of
متن کاملAntibody engineering and therapeutics conference
Half-day pre-conference workshops on three-dimensional (3D) structure antibody modeling and on identifying clonal lineages from next-generation data sets of expressed VH gene sequences will be held on Sunday December 8, 2013. The modeling workshop will be moderated by Juan Carlos Almagro (Pfizer, Inc and Gary L Gilliland (Janssen R&D, Inc. With the success of antibody-based therapeutics, protei...
متن کاملDesign of siRNA Therapeutics from the Molecular Scale
While protein-based therapeutics is well-established in the market, development of nucleic acid therapeutics has lagged. Short interfering RNAs (siRNAs) represent an exciting new direction for the pharmaceutical industry. These small, chemically synthesized RNAs can knock down the expression of target genes through the use of a native eukaryotic pathway called RNA interference (RNAi). Though si...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Journal
سال: 2010
ISSN: 1742-464X
DOI: 10.1111/j.1742-4658.2010.07902.x